The New Paradigm Gene Therapy - 965 Words

Gene therapy, the experimental strategy that requires the use of genes to prevent and cure diseases is a fairly new technique, yet it is one which has shown steady advancements. The journal article â€Å"Gene therapy clinical trials worldwide to 2012—An update† sets out to present analysis and summaries of clinical trials that have been performed worldwide. Authors Samantha L. Ginn, Ian E. Alexander, Michael Edelstein, Mohammad R. Abedi and Joanne Wixon dive into some of the 1843 gene therapy trials performed in 31 countries. Analyzing geographical distribution of trials, searching for indications of mishaps in trials, speaking on diseases which have been tested in trials and a general introduction to gene therapy are some of the points within the article. The new paradigm gene therapy, is one that houses extraordinary potential dating back to its first successful debut in the year 2000. In its debut gene therapy targeted X-linked severe immunodeficiency (SCID-X1). This disease is usually found in early infancy and can be characterized by reoccurring infections. 20 infants underwent gene therapy and after 9 years 8 remained alive. This opened doors for gene therapy as the original option, finding a matched donor, typically has less of a survival rate. However 30 months out of treatment one patient developed T cell leukemia as a direct result of the gene therapy, raising red flags early on. A further three patients also developed T cell leukemia and as a result it was decidedShow MoreRelatedThe Therapeutic Potential of Gene Therapy1334 Words   |  6 PagesA novel therapeutic modality, gene therapy is the transfer of nucleic acids – DNA or RNA – into select somatic (body) cells to correct genetic defects or produce thera peutic proteins. It can be performed ex vivo (â€Å"out of the living†) or in vivo (â€Å"within the living†). In the ex vivo method, the target cells are removed from the patient, genetically modified, and reintroduced into the patients body. This approach is efficient but limited to easily accessible cells such as epithelial cells (cells coveringRead MoreEmerging Therapies For Sickle Cell Anemia1720 Words   |  7 Pages Emerging therapies for sickle cell anemia Cesi Salmeron Suny Rockland Community College Abstract Sickle cell anemia (SCA) is an inherited disorder that produces sickle or crescent shape red blood cells. Thus, the mutated erythrocytes result in an inadequate supply of oxygen being transported throughout the body. Research shows that among those affected the most with the sickle cell gene are African Americans. In recent years, we have seen a decrease in mortality and morbidity ratesRead MoreWhy The Cancer Experts Support Gene Testing To Diagnose Cancer1055 Words   |  5 PagesCancer Experts Support Gene Testing to Diagnose Cancer Gene testing offers extraordinary benefits for diagnosing and treating various forms of cancer. DNA tests can help guide physicians to the best treatment therapies, and more than 31,000 NHS patients have already had their entire genome sequenced, which many medical professionals suggest should become a standardized medical practice as routine as blood tests or biopsies. [1] Why DNA Holds the Keys to Effective Cancer Treatment InternationalRead MoreThe Importance of the Wise Use of Genetic Engineering1025 Words   |  4 PagesHuman species has been suffering at the hands of disease since their genesis. Our relation with each other is such that if one suffers in pain, his suffering and pain touches rest of the humanity. It is now in our domain to use this new technology called Genetic Engineering to ameliorate human suffering and pain. We should make sure that this technology is only used for the betterment of human species and not selectively. It is indeed horrifying to know that someone wants to use this as a toolRead MoreHow Julia Has A History Of Diabetes1143 Words   |  5 Pagespresented in a manic state as a result of the discontinuation of her drug regiment. After her previous diagnosis of bipolar I disorder, she had been on lithium maintenance for eight years, until just recently. My basis for this diagnosis is based on two paradigms: genetic and neuroscience. According to Julia’s family h istory, her father had been diagnosed with bipolar disorder. Family studies have shown that if one parent has bipolar disorder the risk of the child having bipolar disorder is greater. In otherRead MoreBrain Disorders Affecting Children812 Words   |  4 Pagesare not fully established. A3. Opportunity. The recent genetics results present both a big challenge and an opportunity of being able to uncover new drug targets and to develop novel treatment paradigms for each subclass of ASD based on genotypes. Inspired by Precision Medicine Initiative, ASD therapy needs to shift toward personalized and targeted therapy, according to the specific genetic characteristics for each patient. Once the phenotype-genotype linkages are established, we eventually will beRead MoreThe Human Skin735 Words   |  3 Pagesinï ¬â€šammation and itchy, dry patches of skin. Although no cause has been determined, researchers focus on studying genetic abnormalities and inï ¬â€šuences on a defective epidermal barrier (Sajic, Asiniwasis, Skotnicki-Grant, 2012). Mutations in the ï ¬ laggrin gene, with environmental factors that further damage the skin’s protective barrier, are one of many aspects contributing to the cracked skin and inï ¬â€šammation of atopic dermatitis. Filaggrin is an important protein in corniï ¬ cation that contributes to theRead MoreNeururological Disorders1236 Words   |  5 Pagesenough evidence that proves that this technique will work on treating and possibily curing patients. Stafstrom, C. E., Rho, J. M. (2012, April 9). The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders. Retrieved October 23, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321471/ A new treatment for a type of drug-resistant epilepsy has now been proven to work on patients. The ketogenic diet may possess anti-epileptogenic properties that along with certain types ofRead MoreSymptoms And Treatment Of Cancer1303 Words   |  6 Pages Cancer, also known as malignant neoplasm, the hallmark characteristic involves uncontrolled proliferation of cells. Under normal conditions cell grow, divide and die, but in cancer cells the defect takes place at the gene level leading to the formation of an abnormal DNA. As genes are the basic control machines of the cell, alteration of any kind may bring devastating consequences, or malignancy. Moreover, in normal cells damage of any kind is taken care by the repair system but in cancer cellsRead MoreThe Founding Of The First Laboratory By Wilhelm Wundt Essay797 Words   |  4 Pagesof hypnosis, bitter medicines, and electric shock. Today treatment consists of therapies, medication, and modern electric shock with very minimal pa in. Unlike other sciences psychology does not posses a paradigm, which dictates the overall structure for the field. Psychology to this day remains without a paradigm because it lacks a unifying model to indicate which phenomena should be studied. Instead of a paradigm psychology posses a less encompassing approach called a psychological perspective